With 6--8 million cases per year, urinary tract infections (UTIs) primarily impact women. As many as 85 percent of UTIs are caused by E. coli bacteria, most often a specific form of E. coli known as ExPEC. ExPEC are believed to cause up to 40,000 deaths from bloodstream infections each year. As they get more resistant to antibiotics, ExPEC infections and resulting deaths will rise.