The primary law in the United States that regulates industrial manufacture and use of chemicals, called the Toxic Substances Control Act (TSCA), is now 30 years old and has proved largely ineffective in restricting problem chemicals in commerce or in minimizing or mitigating their harm to humans and the environment. It has also failed to effectively stimulate the development and marketing of safer chemicals and products. Basic toxicity information that is publicly available exists for only a small percentage of the thousands of chemicals in commerce.